The Senior Research Program Administrator (SRPA) supports the VBRI Director (VBRID) in all aspects of research operations to maintain a competitive, rigorous, and continuously extramurally funded research program. Under the direction of the VBRID, the SRPA independently manages day-to-day activities of the VBRID's research program(s), including its laboratory-based and clinical branches. The SRPA manages, provides direction and guidance to the research team to facilitate the achievement of the program's goals. They support the submission of applications for extramural funding, as well as the performance and administration of funded awards, and assist the VBRID in the identification, implementation, and maintenance of research collaborations within and outside the Milwaukee Regional Medical Center. They serve as a liaison to the clinical research program, coordinate with clinical research teams, assist with development and implementation of industry collaborations, and oversee correlative studies. They manage, train and assist in the mentorship of early career faculty, research personnel, postdoctoral fellows, and students, manage program finances, and collaborate with the lab managers to ensure efficient, sustainable use of resources. The SRPA works closely with divisions across the VBRI including Grants & Contracts, Finance and Human Resources, VBRI partner organizations on the Milwaukee Regional Medical Center campus, and national and international collaborators. This is a dependent position, and the SRPA is not expected to develop their own research program or apply for grant funding in their own name.

Performs laboratory assays and complex experiments to elucidate novel research questions.

Under the direction of the Principal Investigators (PIs) and CTRO Supervisor, is responsible for coordinating research trials from initiation to completion in compliance with regulations and requirements. Manages trial budgets and implements and oversees systems to manage the conduct of the clinical trials and the flow of information among stakeholders. May serve as a team lead or experienced coordinator mentor. May lead a disease function research area.

Under the direction of the Principal Investigators (PIs) and CTRO Supervisor, is responsible for coordinating research trials from initiation to completion in compliance with regulations and requirements. Assists in the management of trial budgets and implements and oversees systems to manage the conduct of the clinical trials and the flow of information among stakeholders.

The Versiti Blood Research Institute (VBRI), located in Milwaukee, Wisconsin, is an academic center for innovative research in hematology to improve health. VBRI science spans the entire research spectrum, from basic mechanistic inquiry to clinical-translational and population-based research. The VBRI currently houses 25 principal investigators with five focuses areas- Hematopoiesis, Glycobiology, Thrombosis and Hemostasis, Transfusion Medicine, and Immunology. The VBRI has started a significant expansion of its research capacity, with the goal of adding 18 new PIs over a 5–7-year period. Designs for a new 60,000 – 80,000 ft2 research building are under development, with completion anticipated for late 2025. We seek to enhance our research program in hematopoiesis, both normal and malignant. Areas of interest include but are not limited to clonal hematopoiesis, hematopoietic stem cell biology, metabolism, glycobiology, computational approaches, lymphoid and myeloid malignancies, and the hematopoietic niche. Investigators at all academic ranks with a research program focused on blood cell development are encouraged to apply. These positions provide attractive start-up packages and outstanding opportunities for collaboration with basic, translational, and clinical investigators. Candidates from diverse backgrounds are strongly encouraged to apply. The VBRI is located on the same campus as the Medical College of Wisconsin (MCW), Children’s Hospital of Wisconsin, and Froedtert Hospital, which facilitates collaboration, provides additional research breadth, and enables access to graduate students. VBRI faculty typically hold an appointment at MCW, including clinical departments, to facilitate translational research. Entirely focused on hematology, the VBRI provides a unique environment for hematology research, reflected by its long record of scientific excellence and innovation since its founding over seventy years ago. Starting with the recent recruitment of Dr. Michael Deininger, an international leader in myeloproliferative neoplasms, the VBRI is strategically strengthening its programs in malignant hematology and hematopoiesis to promote both mechanistic and clinical-translational science. We are committed to impactful, rigorous science that can change lives.Who are we looking for?Eligible candidates will have an M.D. and/or Ph.D. or equivalent doctoral degree. Candidates of all academic ranks are welcomed. Successful candidates will have track records of creativity and productivity, a desire to integrate into our exciting, collaborative, and growing community of researchers, and a dedication to contributing to our values of diversity and openness. They will be expected to develop a productive and innovative research program, obtain extramural funding, and participate actively in education, training, and mentorship. The VBRI works to attract, design, and retain a diverse workforce and faculty body that reflects the community we serve. We believe that societal change requires actions, not words, and are deeply committed to diversity of backgrounds, experiences, and thought to advance excellence in science and medicine. How do you apply?Qualified applicants should submit a single pdf containing a cover letter, CV, summary of research accomplishments, and future research plans (four pages maximum) and request up to four letters of recommendation be sent to hemsearchBRI@versiti.org. Versiti is committed to increasing the diversity of its faculty and strongly encourages applications from individuals in groups that are underrepresented in the biomedical sciences. Versiti is an affirmative action/equal opportunity employer and does not discriminate in hiring or employment based on age, sex, race, color, religion, national origin, veteran status, disability, or sexual orientation. Milwaukee| versiti.org/careers/living-in-milwaukee. Located on the west side of beautiful Lake Michigan in Wisconsin, Milwaukee is a well-kept secret of affordable quality of life. The city boasts a range of museums, some of the nation's largest summer festivals, a multi-cultural population rich in culinary and artistic tradition, a progressive downtown area, and many outdoor recreation opportunities, including plenty of parks, river walks, and public beaches. Housing is affordable, public, and parochial schools are excellent, and traffic is a breeze. Milwaukee neighborhoods are known for variety, character, and unique architecture, offering superb quality of life and exceptional work-life balance in a city rife with history. With Chicago only 75 minutes away, world-class cultural and sporting venues and one of the world’s busiest air travel hubs are within easy reach. #VBRI

 Postdoctoral fellow in Leukemia and Stem Cell research – Deininger Lab The Deininger lab’s expertise is translational research in leukemia, specifically the biology of myeloid malignancies and the development of molecular targeted therapies. We strive to understand the molecular mechanisms allowing leukemia cells to survive treatment and use this knowledge to develop more effective and less toxic therapies. We employ a multidisciplinary approach to research, straddling genetics, biochemistry, molecular biology, pharmacology, and biomedical engineering, with one goal: improving the lives of patients affected by leukemia. We are proud of our vibrant, diverse, and inclusive team of scientists who strive to improve the prevention, diagnosis, and treatment of myeloid malignancies. Our research program is supported by several NIH (R01s), and several other prestigious private awards. Our labs are located in the Versiti Blood Research Institute (VBRI), an academic institute entirely focused on hematology (https://versiti.org/versiti-blood-research-institute). VBRI is a leader in the field of thrombosis, hemostasis, benign/malignant hematopoiesis and genetic disorders such as Sickle Cell Disease, Von Willebrand’s Disease and hemophilia. VBRI’s close association with the Versiti Medical Sciences Institute, the Versiti Blood Center of Wisconsin, the Medical College of Wisconsin and the clinical hematology programs Froedtert Hospital and Children’s Hospital of Wisconsin ensures strong translational training and accessibility to invaluable resources such as patient tissue/blood samples. VBRI is committed to developing the careers of early career investigators in the field of basic and translational hematology. Each trainee and their PI design a individual development plan (IDP) to define goals, mutual expectations, and support. Most of Dr. Deininger’s trainees have remained in science, and many are now leading their own independent research programs.  Position summaryYou will join a well-established group focused on conducting and completing projects leading to publications in high-impact journals. Under the direction of Dr. Deininger, the successful applicant will lead and develop projects related to myeloid malignancies. They will be trained in and apply advanced laboratory techniques and acquire skills in key aspects of biomedical research, setting them on a trajectory to be successful as principal investigators in academia or group leaders in industry. This is a training position with an expected duration of at least 2 years.  Postdoctoral fellows at Deininger lab have the following responsibilities:- Lead projects by designing and performing experimental procedures - Manage data, analyze, present and report results- Write scientific papers and grants- Work with the PI and other team members to perform experiments in vitro and in vivo Required skills and qualifications- Previous experience in working with animal models of human cancers, molecular biology, immunology, cancer biology, genetics, sequencing, or protein structure is required. - Strong background and profound knowledge in hematological malignancies is preferred.- Evidence of scientific rigor and excellence as documented by peer-reviewed publications.- Ability to work productively in a team and excellent communication skills.- Demonstrated ability to independently apply understanding of scientific theory to the design and execution of research experiments. - Demonstrated ability to interpret and explain the theoretical basis of the work performed. - Proficiency in basic and sophisticated experimental tests and procedures. - Exceptional organizational skills.- Strong orientation to detail.- Deep analytical skills. - Excellent problem-solving skills. - Ability to prioritize and execute multiple tasks simultaneously and meet deadlines. - Exemplary work ethics. Recent relevant publications: - Eide, Christopher A., et al. "Combining the allosteric inhibitor asciminib with ponatinib suppresses emergence of and restores efficacy against highly resistant BCR-ABL1 mutants." Cancer Cell 36.4 (2019): 431-443.- Yan, Dongqing, et al. "SIRT5 is a druggable metabolic vulnerability in acute myeloid leukemia." Blood cancer discovery 2.3 (2021): 266-287.- Zhao, Helong, et al. "MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis." Blood, The Journal of the American Society of Hematology 139.5 (2022): 761-778. For more information about Dr. Deininger lab, please review: https://versiti.org/versiti-blood-research-institute/investigator-laboratory-sites/michael-deininger-laboratory Position informationVersiti follows the NIH stipend levels as outlined by the Kirchstein - NRSA. This full-time trainee position will provide a salary according to the NIH scale, which is dependent upon the years of postgraduate experience. Versiti offers compensated trainees:- Group Dental, Vision, Life, and Disability coverage- Paid Time Off - Paid institutional holidays- 401K matched retirement plan If you are interested in joining us, please mail your CV, a brief statement of research interests and contact information to Nataly Cruz-Rodriguez. ncruz@versiti.org #VBRI

The Versiti Blood Research Institute (VBRI) is an academic center for innovative hematology research in WI. VBRI research spans the spectrum from basic, mechanistic inquiry to clinical- translational and population-based research and currently houses 26 faculty with five focus areas- Hematopoiesis, Glycobiology, Thrombosis and Hemostasis, Transfusion Medicine, and Immunology. To increase the critical mass of hematology investigators assembled under the same roof, VBRI will be adding 18 new PIs over a 7-year period. Designs for a new research building are nearing completion, with groundbreaking slated for the summer of 2024, and completion anticipated in the middle of 2026. This state-of-the-art building will add 80,000 ft2 new space, almost doubling our research capacity.We are seeking to recruit a program leader to expand our Immunology Program from five to up to ten faculty over the next five years. The ideal candidate will have an immunology-focused research program with a track record of outstanding scientific achievement, continuous extramural support, and success at mentorship consistent with a Full Professor. Accomplished scientists whose research includes cancer immunology, autoimmunity, and T-cell biology are encouraged to apply. The successful candidate will be charged to develop a compelling vision for the Immunology Program and enhance its visibility and impact. They will recruit outstanding faculty and mentor them to academic success, as demonstrated by high-impact publications and NIH-type grants. The Immunology Program leader will report to the VBRI Director, Dr. Michael Deininger, and have a seat on the VBRI Executive Council (VEC), which shapes the strategy for the entire institute. Resources available for the new leader include an endowed chair, the ability to recruit several new faculty, and a generous start-up package for their own research program. The VBRI is located on the Milwaukee Regional Medical Center (MRMC), which encompasses the Medical College of Wisconsin (MCW), Children's Wisconsin, Froedtert Hospital, and the VBRI. Appropriately qualified candidates will be presented with additional leadership opportunities in the MRMC.This position provides attractive extensive opportunities for collaboration with basic, translational, and clinical investigators. Candidates from diverse backgrounds are strongly encouraged to apply. The VBRI’s location on the MRMC facilitates collaboration, provides additional research breadth, and enables access to graduate students. To facilitate translational research, VBRI faculty typically hold a second appointment at an MCW department, including clinical departments. MCW is home to a rich immunology community that includes the Department of Microbiology and Immunology, Center for Immunology, Center for Blood and Marrow Transplantation Research (CIBMTR), and the Clinical and Translational Science Institute (CTSI) of Southeastern Wisconsin. The MCW Cancer Center will soon relocate into a new facility, with investment in innovative technologies, including metabolomics, glycobiology, and cryo-electron microscopy, amongst others. The academic landscape is enriched by several Milwaukee-area universities, including the University of Wisconsin Milwaukee, Marquette University, and the Milwaukee School of Engineering.The VBRI provides a unique environment for research given its focus on hematology and its long record of scientific excellence and innovation since its founding over seventy years ago. Starting with the recruitment of Dr. Michael Deininger in 2021, an international leader in malignant  hematology, the VBRI is strategically strengthening its programs in immunology and stem cell biology to advance our goal of becoming an international destination for hematology research. We are committed to impactful, rigorous science that can change lives.Who are we looking for?Eligible candidates have an M.D. and/or Ph.D. or equivalent doctoral degree and a CV consistent with a Full Professor. The successful candidate will have a scientific record of creativity and productivity, a desire to integrate into our exciting, collaborative, and growing community of researchers, and a dedication to contributing to our values of diversity and openness. They will be expected to bring a productive and innovative research program and participate actively in education, training, and mentorship while leading and growing the Immunology Program. Proven academic leadership skills and the ability to navigate a complex campus are a plus. The VBRI works to attract, design, and retain a diverse workforce and faculty body that reflects the communities we serve. We believe that societal change requires actions, not words, and are committed to diversity of backgrounds, experiences, and thought to advance excellence in science and medicine.How do you apply?Qualified applicants should submit a single pdf containing a cover letter, CV, summary of research accomplishments, future research plans (4 pages maximum), leadership statement (1 page limit), and statement on diversity, equity, and inclusion (1 page limit). Please address the letter to Drs. Xue-Zhong Yu and Qizhen Shi, who lead the search committee. All documents should be sent to programleaderimmunology@versiti.orgby May 15, 2024. Versiti is committed to increasing the diversity of its faculty and strongly encourages applications from individuals in groups that are underrepresented in the biomedical sciences. Versiti is an affirmative action/equal opportunity employer and does not discriminate in hiring or employment based on age, sex, race, color, religion, national origin, veteran status, disability, or sexual orientation. Milwaukee| versiti.org/careers/living-in-milwaukee. Located on the west side of beautiful Lake Michigan in Wisconsin, Milwaukee is a well-kept secret of affordable quality of life. The city boasts various museums, some of the nation's largest summer festivals, a multi-cultural population rich in culinary and artistic tradition, a progressive downtown area, and many outdoor recreation opportunities, including many parks, river walks, and public beaches. Housing is affordable, public, and parochial schools are excellent, and traffic is a breeze. Milwaukee neighborhoods are known for variety, character, and unique architecture, offering superb quality of life and exceptional work-life balance in a city rife with history. With Chicago only 75 minutes away, world-class cultural and sporting venues and one of the world's busiest air travel hubs are within easy reach. #VBRI

Exciting Opportunities in Immunology Research The Versiti Blood Research Institute (VBRI) is seeking to recruit independent investigators at a level equivalent to Assistant, Associate Professor or Professor in Immunology. Immunology Faculty PositionsVBRI is seeking innovative researchers who can drive vigorous independent research. Strong candidates in all areas of immunology, particularly in the areas of autoimmunity, lymphocyte biology, innate immunity and cellular therapies are encouraged to apply. Our collaborative team of immunologists includes experts in areas such as autoimmunity, B, T and NK cell biology, and immune regulation. Why Join the Versiti Blood Research Institute?The VBRI is part of Versiti, a not-for-profit organization focused on all aspects of hematology, including diagnostic testing, supply of blood products, and leading-edge basic, clinical  and translational research. The VBRI currently houses 25 principal investigators grouped in 4 research programs (Thrombosis, Hemostasis, Vascular Biology; Hematopoiesis; Transfusion Medicine and Cell Therapy; Immunobiology). A a significant expansion of research capacity is underway, with plans to add 18 new PIs over a 5–7-year period. Designs for a state-of-the-art new 60,000 – 80,000 ft2 research building are near completion, with ground breaking anticipated for early 2024. Upgrading and renovation of existing research space is in progress. Located on the Milwaukee Reginal Medical Campus, the VBRI entertains extensive collaborations with the Medical College of Wisconsin (MCW), Children’s Hospital of Wisconsin, and Froedtert Hospital. VBRI researchers have access to graduate students, but are free of formal teaching obligations. The VBRI is committed to attracting and retaining a diverse workforce and faculty body. Our Immunology Program is renowned for its collaborative environment, state-of-the-art facilities, and unwavering commitment to improving lives through groundbreaking immunological research. VBRI faculty typically hold an appointment at MCW, including clinical departments, to facilitate basic and translational research, aided by membership in the Center for Immunology and Cancer Center. Who are we looking for?We are seeking to recruit faculty with an M.D., Ph.D., or an equivalent doctoral degree. Successful candidates will have a track record of creativity and productivity, a desire to integrate into our dynamic, collaborative, and rapidly expanding research community, and a commitment to our core values of diversity, inclusion, and equity. Successful candidates are expected to develop a productive and innovative research program, obtain extramural funding, and participate actively in education, training, and mentorship. How do you apply?Qualified applicants should submit a single pdf containing a cover letter, CV, summary of research accomplishments and future research plans (four pages maximum), along with names and contact information for up to four references to be sent toDemin Wang, PhD, Chair of the Immunology Search Committee, at  immunologysearch@versiti.org. Versiti is committed to increasing the diversity of its faculty, and strongly encourages applications from individuals from groups that are underrepresented in the biomedical sciences. Versiti is an affirmative action/equal opportunity employer and does not discriminate in hiring or employment based on age, sex, race, color, religion, national origin, veteran status, disability, or sexual orientation. Scan the QR code for more information.Milwaukee|milwaukee.org. Located on the west side of Lake Michigan in Wisconsin, Milwaukee is a well-kept secret of affordable quality of life. The city boasts a range of museums, some of the nation's largest summer festivals, a multi-cultural population rich in culinary and artistic tradition, a progressive downtown area, and many outdoor recreation opportunities, including plenty of parks, river walks, and public beaches. Housing is affordable, public and parochial schools are excellent, and traffic is a breeze. Milwaukee neighborhoods are known for variety, character, and unique architecture, offering superb quality of life and exceptional work-life balance in a city rife with history. With Chicago only 75 minutes away, world-class cultural and sporting venues and one of the world’s busiest air travel hubs are within easy reach. #VBRI

Under the direction of the Principal Investigator, performs laboratory assays and complex experiments to elucidate novel research questions.

 A postdoctoral position is available at NIH-funded lab to study the mechanism of pulmonary thrombosis in SICKLE CELL DISEASE. The lab is interested in studying the role of thrombosis in promoting lung injury in Sickle Cell Disease. The prospective candidate will have the opportunity to learn state-of-the-art techniques such as Multi-Photon-Excitation intravital microscopy of the lung and other organs in live mice, ex vivo microfluidic platform studies with human blood, proteomics and transcriptomics, isolation/characterization of extracellular vesicles in plasma and other molecular biology and biochemistry techniques. Previous experience in studying thrombosis, coagulation or neutrophil/platelet biology is highly preferred. Experience in mice surgery or intravital microscopy, microfluidic platforms and strong background in platelet biology, coagulation and thrombosis is highly preferred. Our labs are located in the Versiti Blood Research Institute (VBRI) of the Blood Center of Wisconsin and the Medical College of Wisconsin in Milwaukee. VBRI is a pioneer institute in the field of Hemostasis, Thrombosis and bleeding disorders. VBRI has a strong commitment towards career development of young investigators in the field of basic and translational hematology. Postdoc candidates will also have the opportunity to learn basic and clinical hematology, innate immunity, thrombosis, platelet biology and pulmonary vascular biology. Please send a brief cover letter, CV and the names and contact information of 3 references to: Prithu Sundd, PhD. Strong written and verbal skills in English are essential. PhDs from Cell Biology, Bioengineering, Biophysics, Biochemistry, Physiology, Immunology, pharmaceutical sciences, Pathology and Molecular Biology who aspire to establish themselves as independent investigators in pulmonary thrombosis are highly encouraged to apply. Versiti Blood Research Institute is a leader in the field of thrombosis, hemostasis, benign/malignant hematology and genetic disorders like Sickle Cell Disease, VWF disease and hemophilia. VBRI’s close association with the Versiti Medical Sciences Institute, the Versiti blood center of Wisconsin, the Medical College of Wisconsin and the Adult as well as Pediatric Sickle Cell Clinic at the Froedtert hospital and Children’s Wisconsin Hospital ensures strong translational training and accessibility to invaluable resources such as tissue/blood samples from patients with Sickle Cell Disease and other rare blood disorders. VBRI and the Milwaukee Regional Medical Center are located in Wauwatosa, which is a peaceful and beautiful suburb of Milwaukee, the second largest city in Mid-West US with affordable living cost. Milwaukee, situated on the shore of beautiful lake Michigan enjoys all four seasons and provides all the charms of a big city. In addition, the close proximity to Chicago city (70 miles) ensures accessibility to all the attractions in the city of Chicago. Travel to and from Milwaukee is convenient through either Milwaukee General Mitchell Airport or Ohare Chicago International Airport. Ohare Chicago is only 63 miles from Milwaukee and easily accessible via car, bus or train provides a convenient means of international air travel with direct flights to most destinations in the world.