Under the direction of a Principal Investigator, further develops and expands understanding of scientific theory in his/her area of interest. Incumbent also learns and applies scientific laboratory techniques and gains experience in other areas of research that will lead to increased probability of success as an independent scientist. This is a training position with an expected duration of 1 – 3 years.  The Zheng Laboratory studies the interactions between lipoprotein metabolism and blood clot lysis. Fibrinolysis, the primary mechanism that dissolves a blood clot, is initiated by a serine protease tissue-type plasminogen activator (tPA). Our previous study discussed a novel source and regulation of endogenous basal plasma tPA derived from hepatocytes, which is important for...

Under the direction of a Principal Investigator, further develops and expands understanding of scientific theory in his/her area of interest. Incumbent also learns and applies scientific laboratory techniques and gains experience in other areas of research that will lead to increased probability of success as an independent scientist. This is a training position with an expected duration of 1 – 3 years.  The Wen Lab has two different, but interconnected research focuses. One focus of the Wen lab is aimed at understanding the signaling pathways that govern proper B and T cell activation and communications and how aberrant signaling in T and B cells will lead to human diseases. The lab has studied the mechanisms by which molecules in antigen receptor signaling pathways such as:...

Performs laboratory assays and complex experiments to elucidate novel research questions. The Zhu Lab is primarily focused on unraveling the mechanisms of receptor transmembrane signaling. Specifically, our attention is directed towards cell surface receptors featuring single transmembrane domains, such as integrins, receptor tyrosine kinases, and receptor-like tyrosine phosphatases. Through a multidisciplinary approach encompassing structural biology, protein engineering, biochemistry, and cell biology techniques, we aim to elucidate how these receptors transmit signals across the cell membrane. Our investigations center on understanding the conformational regulation triggered by ligand binding at the extracellular domain or cytoplasmic domain stimulations. Our goal is to illustrate...

About VBRI and its Immunology ResearchThe Versiti Blood Research Institute (VBRI) is a private research institute and leader in blood-related research, spanning fundamental mechanisms to clinical and translational studies. Home to 30 principal investigators, the faculty benefit from a research-focused environment with minimal teaching obligations while mentoring graduate students and postdoctoral fellows. As part of a strategic growth initiative, VBRI plans to recruit 18 new faculty members over the next 5–7 years and complete a state-of-the-art expansion (60,000–80,000 ft²) by the end of 2026.VBRI immunologists conduct collaborative research on autoimmunity; B, T, and NK cell biology; and immune regulation, with opportunities for cross-disciplinary collaboration. They have access...

Develops and elucidates scientific aims, experimental design and execution. A Research Scientist I is equivalent to the Research Assistant Professor position at many universities. The Zhu Lab is primarily focused on unraveling the mechanisms of receptor transmembrane signaling. Specifically, our attention is directed towards cell surface receptors featuring single transmembrane domains, such as integrins, receptor tyrosine kinases, and receptor-like tyrosine phosphatases. Through a multidisciplinary approach encompassing structural biology, protein engineering, biochemistry, and cell biology techniques, we aim to elucidate how these receptors transmit signals across the cell membrane. Our investigations center on understanding the conformational regulation triggered by ligand binding...

Under the direction of a Principal Investigator, further develops and expands understanding of scientific theory in his/her area of interest. Incumbent also learns and applies scientific laboratory techniques and gains experience in other areas of research that will lead to increased probability of success as an independent scientist. This is a training position with an expected duration of 1 – 3 years.  At the crossroads of metabolism, immunity, and aging The Xian lab’s long-term goal is to enhance immune therapies by uncovering how mitochondrial stress activates the immune system. We focus on how mitochondria-released danger signals—known as danger-associated molecular patterns (DAMPs)—shape immunity. In particular, we study circulating oxidized mitochondrial DNA (Ox-mtDNA),...

Faculty Positions in Basic and/or Translational Blood ResearchWe seek to grow our Transfusion Medicine, Vascular Biology and Cell Therapy Program by recruiting innovative investigators with research interests in blood research and related fields such as transfusion science, cell therapy, gene therapy, glycobiology, and vascular biology. Applicants at all academic ranks with Ph.D., M.D., or equivalent degrees are encouraged to apply. Ideal candidates will develop or maintain independently funded basic and/or translational research programs. These positions provide attractive start-up packages and outstanding opportunities for collaboration with basic, translational, and clinical investigators. The VBRI is located on the same campus as the Medical College of Wisconsin (MCW), Children’s...