Develops, improves, and implements laboratory techniques and performs complex experiments or tests to contribute to the timely and accurate completion of the research project(s). The Pradhan-Sundd Lab has research interests in the following areas: The role of hemolysis in sickle cell disease organ injury:Hemolysis is a key characteristic of sickle cell disease (SCD) that contributes to the disease pathogenesis and clinical heterogeneity. In SCD, cell free hemoglobin and its byproducts (heme and iron) cause vasculopathy as well as a slew of clinical consequences, including liver failure. Although liver injury affects up to ~40% of hospitalized SCD patients, therapeutic approaches to prevent liver injury in SCD are limited. In the Pradhan-Sundd lab we are interested in...

Under the direction of a Principal Investigator, further develops and expands understanding of scientific theory in his/her area of interest. Incumbent also learns and applies scientific laboratory techniques and gains experience in other areas of research that will lead to increased probability of success as an independent scientist. This is a training position with an expected duration of 1 – 3 years.  At the crossroads of metabolism, immunity, and aging The Xian lab’s long-term goal is to enhance immune therapies by uncovering how mitochondrial stress activates the immune system. We focus on how mitochondria-released danger signals—known as danger-associated molecular patterns (DAMPs)—shape immunity. In particular, we study circulating oxidized mitochondrial DNA (Ox-mtDNA),...

Provides data analysis, integration, and development of new computational methods to analyze and integrate genome wide datasets from transcriptome, epigenomic, and other types of functional genomics-based approaches.

Under the direction of a Principal Investigator, further develops and expands understanding of scientific theory in his/her area of interest. Incumbent also learns and applies scientific laboratory techniques and gains experience in other areas of research that will lead to increased probability of success as an independent scientist. This is a training position with an expected duration of 1 – 3 years.  The Sundd Lab is an NIH-funded lab that studies the role of inflammasome, nucleic acid sensing and interferon signaling in neutrophils and platelets in the pathophysiology of vaso-occlusion, lung injury and sterile inflammation in Sickle Cell Disease. The prospective candidate will have the opportunity to learn state-of-the-art techniques such as Multi-Photon-Excitation intravital...